Healthy Aging

The Ultimate Guide to Anti-Aging Supplements for Healthy Aging

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The Ultimate Guide to Anti-Aging Supplements for Healthy Aging about Stem Cell Restore

Aging is a natural process that comes with its own set of challenges and rewards. Staying healthy enough to live independently throughout your life can be an excellent goal. But did you know that certain supplements could help you age gracefully, live independently, and optimize your health?

In this guide, we’ll explore the science behind the aging process and introduce you to some of the most effective and trusted anti-aging supplements that can help you maintain a vibrant, healthy lifestyle. Are you ready to discover the secrets to healthy aging? Let’s dive in!

Key Takeaways

  • Unlock the secrets of why you age and how to achieve healthy aging with anti-aging supplements.

  • How to choose safe and effective supplements to support optimal cellular health, reduce inflammation, and increase longevity.

  • Incorporate your supplements into an effective anti-aging lifestyle for vibrant wellbeing and a long health-span-- that's your time living in good health.

Why You Age: The Science Behind the Aging Process

a mixed race senior woman holding her puppy outdoors

Choosing the best anti-aging supplements to support healthy aging relies on a thorough understanding of the aging process. The aging process is influenced by many factors, including genetics, environment, and lifestyle choices. As we age, our cells become less resilient, and our immune system becomes less efficient in fighting off infections and illnesses. One key driver of aging is chronic inflammation.

Chronic Inflammation Steals Your Youth

Chronic inflammation is a key characteristic of nearly every chronic disease, or so-called diseases of aging. This inflammation has been dubbed "inflammaging" by researchers. The process is linked with chronic morbidity, frailty, disability, and premature death. Inflammaging is a central factor in heart disease, chronic kidney disease, cancer, diabetes, depression, dementia, and sarcopenia (muscle wasting) and the list goes on.

Inflammation can also affect your telomeres. Telomeres are the "caps" on the ends of chromosomes that protect the DNA from damage. This is good, but there's one major downside. Every time the cell divides, telomeres get shorter. And when they hit their shortest possible point, the cell dies.

Then there's stem cells...

Stem Cells: Your Body's Fountain Of Youth

Stem cells are a unique type of cell with the remarkable ability to develop into many different cell types in the body. They serve as the body's natural repair system, replenishing and regenerating cells and tissues throughout a person's life. Stem cells are characterized by two essential properties:

  1. Self-Renewal: Stem cells can divide and produce more identical stem cells, maintaining a pool of undifferentiated stem cells. This property allows them to persist throughout life and serve as a source for specialized cells as the body needs them.

  2. Differentiation: Stem cells can differentiate into specialized cell types with specific functions. This process can include becoming muscle cells, nerve cells, blood cells, and many other cell types, depending on the body's needs.

Stem cells also play a role in maintaining telomere length. Since telomere shortening is associated with aging, researchers believe that stem cells with longer telomeres may have greater regenerative potential. Researchers are investigating ways to extend telomeres in stem cells to improve their regenerative abilities but the research is very early.

Of course, as individuals age, the regenerative capacity of their stem cells declines. This reduced functionality of stem cells can lead to decreased tissue repair and an increased susceptibility to age-related diseases.

Top Anti-Aging Supplements for Optimal Health and Longevity

gel capsules

Vitamins and nutrients play a critical role in maintaining cellular health and promoting optimal aging. Research suggests that anti-aging vitamins, minerals, flavonoids, and polyphenols can help nourish the body, maintain its metabolic functions, and even help reverse the aging process.

Omega-3s are one key nutrient for promoting healthy inflammation levels. And collagen, for instance, is a protein that helps maintain skin structure, and supplementing with collagen can help reduce signs of skin aging like wrinkles. But it's only just the beginning...

To help you navigate the world of anti-aging supplements, we’ve compiled a comprehensive list of the top nutrients that promote optimal cellular health and physical longevity. From powerful antioxidants like CoQ10 to essential vitamins and minerals, these supplements have been shown to support various aspects of healthy aging, including cellular energy production, immune function, and cognitive health.

These nutrients are capable of protecting against age-related diseases, reducing inflammation, and enhancing overall health.

Coenzyme Q10 (CoQ10)

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant present in every cell of the body, providing numerous benefits to overall health. CoQ10 supplementation is beneficial for:

  • Improving blood flow and heart health

  • Sustaining energy production in cells

  • Increasing vigor and energy

  • Supporting the electron transport chain, which produces adenosine triphosphate (ATP) – the energy source for our cells.

As you age, your CoQ10 levels naturally decrease putting your health in jeopardy. By supplementing with CoQ10 you'll support your body’s cellular energy production and reduce the risk of age-related diseases, such as cardiovascular disease. We've reported on a new form of CoQ10 that's shown in studies to shave years off of an old cardiovascular system and restore younger cardiovascular health.

Omega-3 Fatty Acids

sources of omega 3 via healthy foods

At least 300 different fatty acids have been identified and more than 20 kinds are found in foods. All fats have important roles in the body, but the two of most interest are two the body can’t make and must obtain from the food we eat.

These essential fatty acids are linoleic acid (omega-6) and alpha-linolenic acid (omega-3).

Since modern ultra-processed diets have an abundance of omega-6, interest has centered on the omega-3 group as beneficial to health, especially since most Americans consume far less than the amounts recommended by health experts.

Researchers at Harvard found omega-3's consistently lower the risk of death. The Harvard team found that those in the top fifth for blood levels of omega-3 fatty acids had a 27 percent lower risk of death compared to the bottom fifth and lived an average of 2.22 years longer.

They also had a 35 percent lower risk of death from heart disease. Omega-3 fatty acids are well-known for their numerous inflammation-fighting health benefits, particularly in regards to heart health, Type-2 diabetes, neurological disorders, and eye disease – all of which are associated with aging.

In addition to these benefits, omega-3 fatty acids can have positive effects on other aspects of health, such as fresher breath, balanced blood sugar levels, and improved digestion.

Fatty fish, walnuts, and chia seeds are excellent sources of omega-3 fatty acids. You can support healthy aging and reduce the risk of age-related conditions by incorporating more food-based omega-3 fatty acids into your diet, or by taking supplements.

Vitamin C

Vitamin C may be one of the most important antioxidants available. That's because it plays crucial roles in immune function, inflammation regulation, heart health, and various biological processes essential for optimal aging.

More than half a century of research has demonstrated vitamin C's role in various aspects of immune health. For example, vitamin C supports both the innate and the adaptive immune systems. It works by stimulating the production and activity of white blood cells, which are essential for fighting infections.

Given that older folks are at greater risk for infections and experience more severe outcomes of infections, supporting the immune system with vitamin C is critical to reducing exposure to circulating pathogens, especially during seasons when infections are more common.

Vitamin C also supports healthier, younger-looking skin. Supplementing with vitamin C can help increase skin hydration, promote collagen production, and protect against wrinkle formation and premature aging caused by sun exposure. In addition, vitamin C supports your skin's barrier against both pathogens and oxidative stress.

Furthermore, vitamin C also supports cognitive health. A study conducted on 80 adults, aged 60 on average, revealed that higher levels of Vitamin C in their blood helped them to better:

  • Pay attention

  • Stay focused

  • Remember things

  • Make decisions

  • Recall and recognize information

Supplementation appears to prevent and treat respiratory conditions.

How can vitamin C do so much?

We've written about how studies indicate that getting extra amounts of this important nutrient may offset some of the deterioration of aging. As an antioxidant it helps neutralize harmful free radicals that can damage DNA, proteins, and lipids in cells. This oxidative damage is a key contributor to the aging process and age-related diseases. By reducing oxidative stress, vitamin C may help slow down the effects of aging on the body.


food rich with resveratrol

Resveratrol is a potent antioxidant found in grapes and blueberries. It may help protect against age-related conditions including diabetes, cancer, and certain neurodegenerative conditions like Alzheimer’s disease.

Natural sources of resveratrol can be found in red wine, grapes, blueberries, cranberries, and dark chocolate. This antioxidant is believed to have numerous health benefits.

In one study, researchers from UCLA gave a group of ten seniors with mild cognitive impairment (MCI) either grape powder or a placebo every day for six months. Both groups received an amount of powder equivalent to 2.25 cups of grapes.

All participants underwent cognitive testing and brain scans at the beginning and end of the study to establish disease progression and brain metabolic function.

At the end of the study, the researchers found that folks in the grape group experienced better metabolic function in areas of the brain linked to memory and cognition. In fact, the grape powder helped them maintain a healthy metabolism in areas of the brain where Alzheimer’s typically appears, a benefit not seen by the placebo group. That's why we formulated Advanced Brain Power with resveratrol, to make getting your daily dose easier and better for your brain than ever before.

Resveratrol also triggers genes that fight aging. Researchers are finding that resveratrol works by interacting with proteins in cells called sirtuins.

Sirtuins are vitally important because of their epigenetic effects. They activate or “turn on” certain genes while they suppress the actions of other genes. What’s more, they’re especially influential in determining how genes respond to stress.

Resveratrol can be consumed in a balanced way through food sources or in a concentrated dose through supplements for maximum benefit. Potential promotion of longevity and protection against age-related diseases can be attained by including resveratrol in your anti-aging regimen.

Collagen Peptides

Collagen is the main structural protein in our skin, bones, and tendons, and it helps promote skin’s firmness and elasticity. As we age, collagen synthesis can decrease, leading to reduced skin elasticity, and increased wrinkles and sagging.

Collagen supplements or collagen peptides can help promote skin suppleness, skin elasticity, reduce the look of fine lines and wrinkles, and help achieve a more youthful complexion by replenishing collagen levels.

Taking collagen supplements may help improve:

  • Skin elasticity

  • Skin hydration

  • Dermal collagen density

  • The discomfort of knee osteoarthritis

It's easier to boost your collagen levels than you think. By incorporating collagen-boosting supplements, such as collagen peptides or herbal extracts such as boswellia, into your anti-aging routine, you can help maintain healthy skin, hair, and joints.

In fact, if you're one of the millions of people who suffer with stiff, rusty, troublesome joints, then boosting your collagen can help you restore your active lifestyle. Triple Joint Relief can help. This powerful natural formula contains boswellia, long revered in Ayurvedic medicine to shut down inflammation, it also supports natural joint health by stimulating your body's production of collagen.

Vitamin D, Calcium, Magnesium, Vitamin K2

skeleton and bones get support from vitamin d, calcium, magnesium and vitamin k2

Vitamin D, calcium, magnesium, and vitamin K2 work together to support bone health and reduce the risk of fractures.

If you take vitamin D-- and we believe virtually everyone should-- it's critical that you also take vitamin K2 with it. They work together to maintain tight control over calcium in the body. In a nutshell, vitamin D controls calcium in the blood. And K2 controls where it goes. Without the K2, you could end up with too much calcium in all the wrong places, such as the arteries.

Magnesium helps regulate hundreds of processes and nutrients in the body, including calcium and potassium. As you age, your ability to store and utilize magnesium in the body decreases. Research shows that long-term insufficiencies of magnesium accelerates cellular aging -- and that many people have those insufficiencies and don't even know it.

Magnesium also supports your heart health and healthy blood pressure. It is important for healthy muscles and nerves as well -- a significant factor for mobility as you age.

Many people have increasing sleep difficulties as they age. Magnesium can help give you a restful sleep and calm.

Magnesium-rich foods are less common than calcium-rich foods, so you could easily have magnesium deficiencies without realizing it. Some signs you may be low in magnesium include: muscle cramping and pain, sleep difficulties, frequent headaches/migraines, high blood pressure, food cravings (especially for sweets or chocolates), heart rhythm changes, and fatigue.

Incorporating vitamin D, calcium, magnesium, and vitamin K2 into your anti-aging regimen can help you maintain a strong and healthy skeletal system as you age as well as support your heart, your brain, your immune system and so much more. That's why we developed Bone & Muscle Defense a revolutionary formula that supports healthy bones and muscles.

Nicotinamide Riboside (NR)

Nicotinamide Riboside (NR) is a precursor to the amazing compound nicotinamide adenine dinucleotide (NAD+), which has numerous positive effects on the body. NAD+ is an essential compound for life as we know it. It plays a major role in many biological processes, such as:

  • Cell survival

  • Metabolism

  • Immune system activity

  • DNA repair

NR is an excellent supplement for increasing NAD+ levels in the body.

This could help to prevent age-related genetic changes and improve cellular signaling. This is important because genetics plays a significant role in how you age. For example, genetic factors can influence how quickly your telomeres shorten and how well your body can repair DNA damage caused by environmental factors, such as UV radiation and toxins. Inherited genetic mutations can increase the risk of age-related diseases. One example is genes related to inflammation and immune function can influence the body's response to age-related inflammatory processes. And then there is genetic influence on your metabolism and energy production, your hormone levels and antioxidant defenses, and the list goes on.

While your genetics play an important role in the aging process, it's critical that you remember how lifestyle choices such as diet, exercise, stress management, and avoiding harmful behaviors like smoking and excessive sun exposure can significantly influence how gracefully you age.

The takeaway is that by supporting healthy aging and reducing the risk of age-related diseases, NR is an important addition to any anti-aging supplement regimen.

Vitamin B Complex

vitamin b complex benefits

Vitamin B Complex is a combination of essential B vitamins that provide numerous health benefits, including B1, B2, B3, B5, B6, B7, B9, and B12.

A growing body of evidence shows vitamin B complex supplements can stall cognitive decline. Researchers from China wanted to explore the relationship between cognitive ability, and the supplements Chinese people take that have known effects on cognition.

Vitamin B contributes to your overall health and wellbeing... including energy metabolism, methylation, DNA repair, and proper immune function. Insufficiency in B vitamins has been linked to neuro-cognitive disorders, mitochondrial dysfunction, immune dysfunction and inflammation.

In aging populations, B vitamin deficiency has been linked to cardiovascular disorders, cognitive dysfunction, osteoporosis, methylation disorders... and can increase the risk of developing degenerative diseases, especially cardiovascular disease, cognitive disease, and osteoporosis.

These vitamins are essential for brain function, cognitive health, energy, and overall well-being. They help convert carbs into energy, maintain glowing skin and healthy eyes, regulate cholesterol levels, produce essential hormones, metabolize proteins and fats, produce DNA, and create red blood cells.

Supporting cognitive health, brain function, and overall well-being can be achieved by incorporating a quality vitamin B complex supplement into your anti-aging routine. A healthy intake of B vitamins is an important factor in promoting optimal aging of your brain and body.


Glutathione is a powerful antioxidant that's so important to good health that it's sometimes called "The Mother of Antioxidants." It's naturally produced in the body and found in every cell in the body, helping to protect against free radicals and oxidative stress, which can damage cells and contribute to aging and disease.

Glutathione aids in detoxifying the body and reducing cellular damage. Glutathione can also help destroy free radicals, and more. That's why it's also known as your body's "master" antioxidant.

Studies show people over 60 with higher blood glutathione levels enjoy better physical health and less chronic disease. Glutathione was shown in studies to be characteristic of long-lived women and found to be elevated in centenarians. In one study, people over 100 had higher levels of glutathione than those aged 70 to 99.

Stress and toxic exposure can also deplete your glutathione levels. Incorporating glutathione into your anti-aging regimen can bolster your body’s natural defense mechanisms against cellular damage and oxidative stress. The easiest way is by supplying your body with glutathione precursors, nutrients that support your body's own natural production of glutathione, in our revolutionary anti-aging formula Vital Force. It contains a patented nutrient known as Setria®, which has shown in clinical studies to support the body's natural production of glutathione. Vital Force also contains the next top anti-aging supplement...

N-Acetyl L-Cysteine (NAC)

N-Acetyl-Cysteine (NAC) is a supplement derived from the amino acid L-cysteine that has many beneficial uses. It's commonly used to promote:

  • Higher glutathione levels

  • Better detoxification

  • Improved liver and kidney function

  • Clearer breathing and help break up mucous

Since NAC is a precursor to glutathione, supplementing with NAC could boost the production of glutathione, potentially reducing inflammation and oxidative stress in your body. Research now demonstrates that NAC may reverse glutathione reduction and help protect neurons.

NAC provides every cell in the body with additional glutathione which is the most powerful antioxidant protection for your cells. NAC is a natural amino acid that's well absorbed from the gut and gets into the blood stream.

One thing NAC is really good for is memory and neurological problems. In fact, we've reported on research that shows NAC can help people with memory loss and Parkinson's disease. In addition, NAC may be helpful for traumatic brain injury. David W. Dodick, a professor of neurology at the Mayo Clinic, says that in case a child receives a head injury at a sporting event – “Every coach and parent could be carrying this on the sidelines.”

I don’t know if this finding has been accepted by the mainstream medical community. Probably not. It’s new and (horrors!) it’s nutritional.

Sea Buckthorn

An exciting new study has shown that sea buckthorn extract shows a positive effect on stem cell activity in the human body.

Sea Buckthorn is a natural source of Omega-7 fatty acids, which can help promote skin health and reduce inflammation. Omega-7 fatty acids can positively reduce inflammation, enhance skin health, and safeguard against heart disease.

In various studies, Sea Buckthorn’s antioxidants, including polyphenols and essential Omega 3 fatty acids, have repeatedly been shown to reduce cognitive decline and improve acute cognitive function in Alzheimer’s patients.

In a recent study by the Institute of Medical Sciences of Banaras Hindu University, scientists treated a number of elderly individuals who suffered from dementia with Sea Buckthorn juice for six months. The results showed an overall improvement in cognitive function; and, that the Sea Buckthorn treatment appeared to be helpful for age related memory and other cognitive deficits.

Including sea buckthorn in your anti-aging regimen can help maintain healthy skin and reduce inflammation. This natural source of Omega-7 fatty acids can be a valuable addition to your overall strategy for healthy aging. That's why our breakthrough Stem Cell Restore anti-aging formula contains a patented form of sea buckthorn, called CyanthOx™30. A Gold-standard clinical human trial conducted on CyanthOx™30 showed evidence that this powerful nutrient can support your body’s own supply of repair stem cells - the cells that work to rejuvenate every other cell in the body.

How to Choose the Right Anti-Aging Supplement

third party lab tested symbol

When choosing an anti-aging supplement, it’s important to consider the following four factors:

  1. Formulas Backed By Science: Select a product with ingredients that are backed by science. Our products are developed based only on the latest science from natural and alternative health, cutting-edge nutrition, and anti-aging medicine.

  2. Quality Control Testing: Ensure the highest quality, safety, and efficacy of any product you choose by checking for independent verification testing. Our products are triple tested by our manufacturers to ensure potency and purity and are stored in our temperature and humidity-controlled warehouse in the Shenandoah Valley, Virginia.

  3. Good Manufacturing Practices: Choose products that are stamped with the certified Good Manufacturing Practices (cGMP) seal to ensure safe, quality manufacturing at ever stage. Here at Green Valley Naturals, we only work with U.S.-based manufacturing facilities that are cGMP compliant and FDA inspected.

  4. 100% Satisfaction Guarantee: When taking any nutritional product you want to see and feel a difference in your health and well-being. At Green Valley, all of our products come with our 90-day Satisfaction Guarantee.

By considering these factors, you can make an informed decision when choosing the best anti-aging supplement.

It’s also crucial to be aware of potential interactions between anti-aging supplements and medications. Consulting with your healthcare provider can help ensure that adding any new and regular supplements is safe for you.

Integrating Supplements into a Healthy Lifestyle

smiling happy healthy middle-aged woman holding glass of water and a pill

Incorporating supplements into a healthy lifestyle is essential for optimal aging. A balanced diet, regular exercise, good sleep habits and stress management are all key factors in promoting a healthy, vibrant life despite your age.

In addition to taking supplements, you can fight aging by consuming a balanced diet rich in nutritious whole-foods including:

  • fruits (preferably organic)

  • vegetables (preferably organic)

  • nuts, seeds

  • fish

  • grass-fed beef

  • whole grains

Eating these nutrient-rich foods can help provide essential vitamins, minerals, healthy fats and amino acids to support healthy aging.


In conclusion, a combination of the right anti-aging supplements and healthy lifestyle choices such as exercise, a healthy diet, good sleep habits and stress management can help you achieve optimal aging and reduce the risk of age-related diseases.

By understanding the science behind aging, incorporating natural sources of the right anti-aging nutrients, and maintaining a balanced diet and lifestyle, you can support a vibrant, healthy life as you get older. It’s time to take charge of your health and embrace the wisdom and experience that comes with age.

Frequently Asked Questions

What supplements can you take to look younger?

Nutrients such as the ones listed above can help slow down the aging process and improve your physical health and overall appearance. Supplements are critical to get the quality and dosage of these nutrients that are shown in the latest science to fight the aging process.

Do anti-aging supplements really work?

Though no supplements can yet reverse aging, they can help slow the process when combined with a healthy lifestyle. Eating a balanced diet, exercising regularly, getting enough sleep and managing stress are all important components of a healthy lifestyle. Additionally, taking certain supplements may help to support your body's natural, healthy function and reduce the effects of aging.

What vitamin makes your skin look younger?

Vitamin E, Vitamin C, and Vitamin A are all powerful anti-aging vitamins that can protect your skin from wrinkles and fine lines, boost collagen production, protect against sun damage, and even out your skin tone. Taken together, these vitamins can help make your skin look younger.

What are some of the most effective anti-aging supplements?

These supplements can help you maintain your health and youthful vitality: CoQ10, Omega-3 fatty acids, Vitamin C, Resveratrol, Collagen peptides, Vitamin D, Calcium, Vitamin K2, Nicotinamide Riboside, Vitamin B complex, Glutathione, N-Acetyl L-Cysteine, and Sea Buckthorn.

How can I support healthy aging through my diet?

Focus on eating a diet rich in fruits, vegetables, nuts, seeds, healthy fats, whole grains and fish for essential vitamins and nutrients to support a healthy body and healthy aging.

Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol. 2023 Oct;97(10):2499-2574. doi: 10.1007/s00204-023-03562-9. Epub 2023 Aug 19. PMID: 37597078; PMCID: PMC10475008.

Srivastava P, Verma AK, Arya JK, Rizvi SI. Modulatory effect of exogenous Coenzyme Q10 on redox and inflammatory biomarkers during aging in rats. Biol Futur. 2022 Dec;73(4):473-481. doi: 10.1007/s42977-022-00140-5. Epub 2022 Nov 28. PMID: 36443592.

Soma M, Lalam SK. The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. Mol Biol Rep. 2022 Oct;49(10):9737-9748. doi: 10.1007/s11033-022-07459-1. Epub 2022 Apr 20. PMID: 35441939.

Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, Chen C. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023 Apr 26;15(9):2080. doi: 10.3390/nu15092080. PMID: 37432180; PMCID: PMC10180699.

Columbia University Irving Medical Center. "Multivitamin improves memory in older adults, study finds." ScienceDaily. ScienceDaily, 24 May 2023. <>.

Lee, J. Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: A double-blinded placebo controlled pilot study. Experimental Gerontology. Volume 87, Part A, January 2017, Pages 121-128

Stem Cell Restore

Stem Cell Restore

Stem Cell Rejuvenation Matrix


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